ARPA-H PATH Study

“Personalised Analytics for Transforming Healthcare” PATH

ENROLLING PATIENTS WITH TYPE-1 DIABETES (T1D) residing near Novato CA. Click here to enroll.

Goal/Objective:

4YouandMe is the lead on Activity 4: Developing a non-invasive data data-driven health metric. This PATH project is coordinated by Lee Hood and the Buck Institute and funded by ARPA-H. We will couple continuous glucose monitors and wearable trackers with gold standard assessments of beta cell function in order to identify passive monitoring signals that could inform beta cell function decline. Such a non-invasive digital health technology (DHT) could monitor T2D development and progression in a free living population, relieving the burden of requiring frequent clinical visits for individuals at risk for T2D and democratizing access to healthcare for this purpose.

Overarching Objectives:

  • Prospectively generate new multiomic data for a targeted cohort of metabolically impaired individuals to profile and understand pancreatic beta-cell function, and

  • Develop a non-invasive assessment of pancreatic beta-cell function by mapping a subset of biological signals indicative of beta cell function to digital wearables.

Impact

The digital health tracker developed as part of this Activity for the profiling of pancreatic beta-cell function is being built to test if it might enable home-based assessments as an alternative to expensive and invasive approaches currently constrained to a clinical or research setting. Ultimately, our approach represents a synergistic blend of state-of-the-art technology and meticulous clinical validation, setting new standards for personalized diabetes care and offering fresh insights into the pathogenesis and progression of T2D, with a strong emphasis on inclusivity and accessibility. In the long term- it is hoped that it will help power the development of a non-invasive digital health technology (DHT) that will catalyze the migration of diabetes care from hospitals to the home.

Size and Timing

This project launched in October 2024 and involved enrolling over 150 individuals. We are actively enrolling patients with Type 1 Diabetes who live near Novato CA, In early 2026 we will enroll pre-diabetics and those with Type 2 diabetes. This project will be completed near the end of 2027.

Coalition and Collaboration partners

This project is done by 4YouandMe in collaboration with The Buck Institute, Phenome Health, AgileOps, and Vector Institute